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Literature summary for 3.4.22.48 extracted from

  • Elmwall, J.; Kwiecinski, J.; Na, M.; Ali, A.A.; Osla, V.; Shaw, L.N.; Wang, W.; Saevman, K.; Josefsson, E.; Bylund, J.; Jin, T.; Welin, A.; Karlsson, A.
    Galectin-3 is a target for proteases involved in the virulence of Staphylococcus aureus (2017), Infect. Immun., 85, e00177-17 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
SspC
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Galectin-3 + H2O Staphylococcus aureus the enzyme has galectin-3-processing capacity ?
-
 ?
Galectin-3 + H2O Staphylococcus aureus the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection ?
-
 ?
Galectin-3 + H2O Staphylococcus aureus NCTC 8325 the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection ?
-
 ?
Galectin-3 + H2O Staphylococcus aureus NCTC 8325 the enzyme has galectin-3-processing capacity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q2FZL3
-
-
Staphylococcus aureus Q2G2R8
-
-
Staphylococcus aureus NCTC 8325 Q2FZL3
-
-
Staphylococcus aureus NCTC 8325 Q2G2R8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Galectin-3 + H2O the enzyme has galectin-3-processing capacity Staphylococcus aureus ?
-
 ?
Galectin-3 + H2O the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection Staphylococcus aureus ?
-
 ?
Galectin-3 + H2O the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection Staphylococcus aureus NCTC 8325 ?
-
 ?
Galectin-3 + H2O the enzyme has galectin-3-processing capacity Staphylococcus aureus NCTC 8325 ?
-
 ?

Synonyms

Synonyms Comment Organism
SCPA
-
 Staphylococcus aureus
SspB
-
 Staphylococcus aureus
staphopain A
-
 Staphylococcus aureus
staphopain B
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production Staphylococcus aureus